Human Chorionic Gonadotropin (HCG) is given as an injection under the skin or into a muscle. HCG is a hormone that supports the normal development of an egg in a woman’s ovary and stimulates the release of the egg during ovulation. HCG helps to become pregnant.
Inceptova HCG is used in the treatment of:
- Pre-pubertal cryptorchidism (not due to anatomical obstruction)
- Hypogonadotropic hypogonadism (hypogonadism secondary to a pituitary deficiency) in males
- Induction of ovulation and pregnancy in the anovulatory, infertile woman in whom the cause of anovulation is secondary and not due to primary ovarian failure, and who has been appropriately pretreated with human menotropins.
- Usual Adult Dose for Ovulation Induction: HCG: 5000–10,000 units IM once 1 day following the last dose of Menotropins.
- Usual Adult Dose for Hypogonadism – Male: 500–1000 units IM 3 times a week for 3 weeks, then 500–1000 units IM 2 times a week for 3 weeks or 4000 units IM 3 times a week for 6–9 months, then 2000 units IM 3 times a week for 3 months.
- Usual Pediatric Dose for Prepubertal Cryptorchidism: Four years and older: 4000 units IM 3 times a week for 3 weeks or 5000 units IM every other day for 4 injections or 500–1000 units IM for 15 injections over a period of 6 weeks or 500 units IM 3 times a week for 4–6 weeks; if unsuccessful, patients should be given an additional series using 1000 units starting 1 month later.
Inceptova HCG may cause the following side effects in women:
- More Common: Bloating (mild), stomach or pelvic pain
- Less Common or Rare: Abdominal or stomach pain (severe); bloating (moderate to severe); decreased amount of urine; feeling of indigestion; nausea, vomiting, or diarrhea (continuing or severe); pelvic pain (severe); shortness of breath; swelling of feet or lower legs; weight gain (rapid).
In men inceptova HCG may cause the following side effects:
Less Common: Acne; enlargement of penis and testes; growth of pubic hair and rapid increase in height
Additionally, inceptova HCG may cause these side effects in men:
- Difficult or labored breathing
- Sudden, unexplained shortness of breath
- Flushing of skin
- Itching of skin
- Redness of skin
- Skin rash
- Hives or welts
- Chest pain
- Severe and sudden headache
- Slurred speech
- Sudden loss of coordination
- Severe weakness or numbness in arm or leg
- Tightness in chest
- Unusually warmth
- Vision changes
- Hypersensitivity: Anaphylaxis has been reported with urinary-derived HCG products.
- Thromboembolism: Arterial or venous thromboembolism may occur, patients with a history or family history of thrombosis, severe obesity or thrombophilia are at an increased risk.
- Asthma: Use with caution in asthma patients.
- Cardiovascular disease: Use with caution in patients with cardiovascular disease.
- Cryptorchidism: May induce precocious puberty in children being treated for cryptorchidism. Discontinue if signs of precocious puberty occur.
- Migraine: Use with caution in patients with a history of migraines.
- Renal impairment: Use with caution in patients with renal impairment.
- Seizure disorders: Use with caution in patients with a history of seizure disorders.
- Hypersensitivity to chorionic gonadotropin or any component of the formulation
- Precocious puberty
- Prostatic carcinoma or other androgen-dependent neoplasms.
- Prepubertal males with signs of anatomical obstruction; sex hormone-dependent tumors (e.g. ovary, breast and uterine carcinoma in females; breast carcinoma males); malformations of the sexual organs incompatible with pregnancy; fibroid tumors of the uterus incompatible with pregnancy.